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lsci technology  (Perimed Inc)

 
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    Perimed Inc lsci technology
    Mice exhibit compensatory decreasing of diastolic blood pressure and increasing tissue perfusion to counteract the hemoglobin deoxygenation effect of Au@PEG NPs. Changes in physiological parameters of mice at different time points after tail vein injection of Au@PEG NPs: (A) Body weight, (B) Pulse rate, (C) Diastolic pressure, (D) Systolic pressure, (E) Pulse pressure (Systolic pressure − Diastolic pressure) ( n = 9). (F) Hepatic blood flow perfusion of mice was monitored at different time points after tail vein injection of Au@PEG NPs using laser speckle contrast imaging <t>(LSCI).</t> (G) Schematic diagram of the bright-field scope of the sampling area using LSCI. (H) Changes in hepatic blood flow perfusion of mice at different time points after tail vein injection of Au@PEG NPs. Physiological parameters measured before tail vein injection of Au@PEG NPs were set as the baseline. Changes in blood routine parameters of mice at different time points after tail vein injection of Au@PEG NPs: (I) WBCs, (J)RBCs, (K) PLTs. Relative expression of oxygen-sensing genes, (L) HIF-1α, (M) EPO, in kidney detected by real-time quantitative PCR and the 2 −ΔΔCT method. (N) Plasma erythropoietin (EPO) concentrations at different time points after tail vein injection of Au@PEG NPs. Asterisks indicate significance (* p < 0.05).
    Lsci Technology, supplied by Perimed Inc, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/lsci+technology/pmc12865628-139-6-10?v=Perimed+Inc
    Average 86 stars, based on 1 article reviews
    lsci technology - by Bioz Stars, 2026-08
    86/100 stars

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    1) Product Images from "PEGylated gold nanoparticles regulate metabolic flux in erythrocytes by inducing hemoglobin deoxygenation"

    Article Title: PEGylated gold nanoparticles regulate metabolic flux in erythrocytes by inducing hemoglobin deoxygenation

    Journal: International Journal of Pharmaceutics: X

    doi: 10.1016/j.ijpx.2026.100495

    Mice exhibit compensatory decreasing of diastolic blood pressure and increasing tissue perfusion to counteract the hemoglobin deoxygenation effect of Au@PEG NPs. Changes in physiological parameters of mice at different time points after tail vein injection of Au@PEG NPs: (A) Body weight, (B) Pulse rate, (C) Diastolic pressure, (D) Systolic pressure, (E) Pulse pressure (Systolic pressure − Diastolic pressure) ( n = 9). (F) Hepatic blood flow perfusion of mice was monitored at different time points after tail vein injection of Au@PEG NPs using laser speckle contrast imaging (LSCI). (G) Schematic diagram of the bright-field scope of the sampling area using LSCI. (H) Changes in hepatic blood flow perfusion of mice at different time points after tail vein injection of Au@PEG NPs. Physiological parameters measured before tail vein injection of Au@PEG NPs were set as the baseline. Changes in blood routine parameters of mice at different time points after tail vein injection of Au@PEG NPs: (I) WBCs, (J)RBCs, (K) PLTs. Relative expression of oxygen-sensing genes, (L) HIF-1α, (M) EPO, in kidney detected by real-time quantitative PCR and the 2 −ΔΔCT method. (N) Plasma erythropoietin (EPO) concentrations at different time points after tail vein injection of Au@PEG NPs. Asterisks indicate significance (* p < 0.05).
    Figure Legend Snippet: Mice exhibit compensatory decreasing of diastolic blood pressure and increasing tissue perfusion to counteract the hemoglobin deoxygenation effect of Au@PEG NPs. Changes in physiological parameters of mice at different time points after tail vein injection of Au@PEG NPs: (A) Body weight, (B) Pulse rate, (C) Diastolic pressure, (D) Systolic pressure, (E) Pulse pressure (Systolic pressure − Diastolic pressure) ( n = 9). (F) Hepatic blood flow perfusion of mice was monitored at different time points after tail vein injection of Au@PEG NPs using laser speckle contrast imaging (LSCI). (G) Schematic diagram of the bright-field scope of the sampling area using LSCI. (H) Changes in hepatic blood flow perfusion of mice at different time points after tail vein injection of Au@PEG NPs. Physiological parameters measured before tail vein injection of Au@PEG NPs were set as the baseline. Changes in blood routine parameters of mice at different time points after tail vein injection of Au@PEG NPs: (I) WBCs, (J)RBCs, (K) PLTs. Relative expression of oxygen-sensing genes, (L) HIF-1α, (M) EPO, in kidney detected by real-time quantitative PCR and the 2 −ΔΔCT method. (N) Plasma erythropoietin (EPO) concentrations at different time points after tail vein injection of Au@PEG NPs. Asterisks indicate significance (* p < 0.05).

    Techniques Used: Injection, Imaging, Sampling, Expressing, Real-time Polymerase Chain Reaction, Clinical Proteomics



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    lsci technology  (Perimed Inc)
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    Perimed Inc lsci technology
    Mice exhibit compensatory decreasing of diastolic blood pressure and increasing tissue perfusion to counteract the hemoglobin deoxygenation effect of Au@PEG NPs. Changes in physiological parameters of mice at different time points after tail vein injection of Au@PEG NPs: (A) Body weight, (B) Pulse rate, (C) Diastolic pressure, (D) Systolic pressure, (E) Pulse pressure (Systolic pressure − Diastolic pressure) ( n = 9). (F) Hepatic blood flow perfusion of mice was monitored at different time points after tail vein injection of Au@PEG NPs using laser speckle contrast imaging <t>(LSCI).</t> (G) Schematic diagram of the bright-field scope of the sampling area using LSCI. (H) Changes in hepatic blood flow perfusion of mice at different time points after tail vein injection of Au@PEG NPs. Physiological parameters measured before tail vein injection of Au@PEG NPs were set as the baseline. Changes in blood routine parameters of mice at different time points after tail vein injection of Au@PEG NPs: (I) WBCs, (J)RBCs, (K) PLTs. Relative expression of oxygen-sensing genes, (L) HIF-1α, (M) EPO, in kidney detected by real-time quantitative PCR and the 2 −ΔΔCT method. (N) Plasma erythropoietin (EPO) concentrations at different time points after tail vein injection of Au@PEG NPs. Asterisks indicate significance (* p < 0.05).
    Lsci Technology, supplied by Perimed Inc, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/lsci+technology/pmc12865628-139-6-10?v=Perimed+Inc
    Average 86 stars, based on 1 article reviews
    lsci technology - by Bioz Stars, 2026-08
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    laser speckle contrast imaging lsci technology  (Perimed Inc)
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    Mice exhibit compensatory decreasing of diastolic blood pressure and increasing tissue perfusion to counteract the hemoglobin deoxygenation effect of Au@PEG NPs. Changes in physiological parameters of mice at different time points after tail vein injection of Au@PEG NPs: (A) Body weight, (B) Pulse rate, (C) Diastolic pressure, (D) Systolic pressure, (E) Pulse pressure (Systolic pressure − Diastolic pressure) ( n = 9). (F) Hepatic blood flow perfusion of mice was monitored at different time points after tail vein injection of Au@PEG NPs using laser speckle contrast imaging <t>(LSCI).</t> (G) Schematic diagram of the bright-field scope of the sampling area using LSCI. (H) Changes in hepatic blood flow perfusion of mice at different time points after tail vein injection of Au@PEG NPs. Physiological parameters measured before tail vein injection of Au@PEG NPs were set as the baseline. Changes in blood routine parameters of mice at different time points after tail vein injection of Au@PEG NPs: (I) WBCs, (J)RBCs, (K) PLTs. Relative expression of oxygen-sensing genes, (L) HIF-1α, (M) EPO, in kidney detected by real-time quantitative PCR and the 2 −ΔΔCT method. (N) Plasma erythropoietin (EPO) concentrations at different time points after tail vein injection of Au@PEG NPs. Asterisks indicate significance (* p < 0.05).
    Laser Speckle Contrast Imaging Lsci Technology, supplied by Perimed Inc, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/lsci+technology/bio_rxiv__64898__2026__02__24__707704-59-8-17?v=Perimed+Inc
    Average 86 stars, based on 1 article reviews
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    Mice exhibit compensatory decreasing of diastolic blood pressure and increasing tissue perfusion to counteract the hemoglobin deoxygenation effect of Au@PEG NPs. Changes in physiological parameters of mice at different time points after tail vein injection of Au@PEG NPs: (A) Body weight, (B) Pulse rate, (C) Diastolic pressure, (D) Systolic pressure, (E) Pulse pressure (Systolic pressure − Diastolic pressure) ( n = 9). (F) Hepatic blood flow perfusion of mice was monitored at different time points after tail vein injection of Au@PEG NPs using laser speckle contrast imaging (LSCI). (G) Schematic diagram of the bright-field scope of the sampling area using LSCI. (H) Changes in hepatic blood flow perfusion of mice at different time points after tail vein injection of Au@PEG NPs. Physiological parameters measured before tail vein injection of Au@PEG NPs were set as the baseline. Changes in blood routine parameters of mice at different time points after tail vein injection of Au@PEG NPs: (I) WBCs, (J)RBCs, (K) PLTs. Relative expression of oxygen-sensing genes, (L) HIF-1α, (M) EPO, in kidney detected by real-time quantitative PCR and the 2 −ΔΔCT method. (N) Plasma erythropoietin (EPO) concentrations at different time points after tail vein injection of Au@PEG NPs. Asterisks indicate significance (* p < 0.05).

    Journal: International Journal of Pharmaceutics: X

    Article Title: PEGylated gold nanoparticles regulate metabolic flux in erythrocytes by inducing hemoglobin deoxygenation

    doi: 10.1016/j.ijpx.2026.100495

    Figure Lengend Snippet: Mice exhibit compensatory decreasing of diastolic blood pressure and increasing tissue perfusion to counteract the hemoglobin deoxygenation effect of Au@PEG NPs. Changes in physiological parameters of mice at different time points after tail vein injection of Au@PEG NPs: (A) Body weight, (B) Pulse rate, (C) Diastolic pressure, (D) Systolic pressure, (E) Pulse pressure (Systolic pressure − Diastolic pressure) ( n = 9). (F) Hepatic blood flow perfusion of mice was monitored at different time points after tail vein injection of Au@PEG NPs using laser speckle contrast imaging (LSCI). (G) Schematic diagram of the bright-field scope of the sampling area using LSCI. (H) Changes in hepatic blood flow perfusion of mice at different time points after tail vein injection of Au@PEG NPs. Physiological parameters measured before tail vein injection of Au@PEG NPs were set as the baseline. Changes in blood routine parameters of mice at different time points after tail vein injection of Au@PEG NPs: (I) WBCs, (J)RBCs, (K) PLTs. Relative expression of oxygen-sensing genes, (L) HIF-1α, (M) EPO, in kidney detected by real-time quantitative PCR and the 2 −ΔΔCT method. (N) Plasma erythropoietin (EPO) concentrations at different time points after tail vein injection of Au@PEG NPs. Asterisks indicate significance (* p < 0.05).

    Article Snippet: Real-time hepatic microcirculation was quantified using LSCI technology (PeriCam PSI, Perimed) following established protocols ( ; ).

    Techniques: Injection, Imaging, Sampling, Expressing, Real-time Polymerase Chain Reaction, Clinical Proteomics